Kruiisid Panama kanalil pakuvad ainulaadset võimaluse läbida mitmeid sadamaid nii Põhja- kui Lõuna-Ameerikas. 1914. aastal valminud Panama kanal on 82 km pikk ja ühendab Vaikset ookeani Atlandi ookeaniga.

Näidismarsruudid:

• Ultimate Panama Canal Cruise
  Miami, Florida > Labadee, Haiti > Willemstad, Curacao > Oranjestad, Aruba > Panama Canal (Cruising Canal) > Cristobal Pier, Panama > Cartagena, Colombia > Miami, Florida
• Panama Canal Cruise
  Los Angeles, California > Puerto Vallarta, Mexico > Acapulco, Mexico > Guatemala City, Guatemala > Puntarenas, Costa Rica > Panama Canal (Cruising Canal) > Cristobal Pier, Panama > Cartagena, Colombia > Miami, Florida
• Caribbean & Panama Canal Cruise
  Miami, Florida > Oranjestad, Aruba > Panama Canal (Cruising Canal) > Cristobal Pier, Panama > Puerto Limon, Costa Rica > George Town, Grand Cayman >  Miami, Florida
• Eastbound Panama Canal Cruise
  San Diego, California > Cabo San Lucas, Mexico > Acapulco, Mexico > Huatulco, Mexico > Puntarenas, Costa Rica > Panama Canal (Cruising Canal) > Cristobal Pier, Panama > Cartagena, Colombia > Fort Lauderdale, Florida
• Westbound Panama Canal Cruise
  San Juan, Puerto Rico > Casa De Campo, Dominican Rep > Cartagena, Colombia > Panama Canal (Cruising Canal) > Puntarenas, Costa Rica > Huatulco, Mexico > Acapulco, Mexico > Cabo San Lucas, Mexico > San Francisco, California